WEB MAPPING ARCHITECTURES BASED ON OPEN SPECIFICATIONS AND FREE AND OPEN SOURCE SOFTWARE IN THE WATER DOMAIN

The availability of water-related data and information across different geographical and jurisdictional scales is of critical importance for the conservation and management of water resources in the 21st century. Today information assets are often found fragmented across multiple agencies that use incompatible data formats and procedures for data collection, storage, maintenance, analysis, and distribution. The growing adoption of Web mapping systems in the water domain is reducing the gap between data availability and its practical use and accessibility. Nevertheless, more attention must be given to the design and development of these systems to achieve high levels of interoperability and usability while fulfilling different end user informational needs. This paper first presents a brief overview of technologies used in the water domain, and then presents three examples of Web mapping architectures based on free and open source software (FOSS) and the use of open specifications (OS) that address different users' needs for data sharing, visualization, manipulation, scenario simulations, and map production. The purpose of the paper is to illustrate how the latest developments in OS for geospatial and water-related data collection, storage, and sharing, combined with the use of mature FOSS projects facilitate the creation of sophisticated interoperable Web-based information systems in the water domain

Core excitation effects in the breakup of halo nuclei

The role of core excitation in the structure and dynamics of two-body halo nuclei is investigated. We present calculations for the resonant breakup of 11Be on protons at an incident energy of 63.7 MeV/nucleon, where core excitation effects were shown to be important. To describe the reaction, we use a recently developed extension of the DWBA formalism which incorporates these core excitation effects within the no-recoil approximation. The validity of the no-recoil approximation is also examined by comparing with DWBA calculations which take into account core recoil. In addition, calculations with two different continuum representations are presented and compared.Ministerio de Ciencia e Innovación FIS2011-28738-c02-01, FPA2009- 07653, FPA2009-08848, CSD2007-00042Junta de Andalucía FQM160, P07-FQM-0289

Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection

SummaryProgression to AIDS is driven by CD4 T cell depletion, mostly involving pyroptosis elicited by abortive HIV infection of CD4 T cells in lymphoid tissues. Inefficient reverse transcription in these cells leads to cytoplasmic accumulation of viral DNAs that are detected by the DNA sensor IFI16, resulting in inflammasome assembly, caspase-1 activation, and pyroptosis. Unexpectedly, we found that peripheral blood-derived CD4 T cells naturally resist pyroptosis. This resistance is partly due to their deeper resting state, resulting in fewer HIV-1 reverse transcripts and lower IFI16 expression. However, when co-cultured with lymphoid-derived cells, blood-derived CD4 T cells become sensitized to pyroptosis, likely recapitulating interactions occurring within lymphoid tissues. Sensitization correlates with higher levels of activated NF-κB, IFI16 expression, and reverse transcription. Blood-derived lymphocytes purified from co-cultures lose sensitivity to pyroptosis. These differences highlight how the lymphoid tissue microenvironment encountered by trafficking CD4 T lymphocytes dynamically shapes their biological response to HIV

Study of the magnetic disaccommodation in La doped YIG

The relaxation of the initial magnetic permeability of La doped yttrium iron garnet (YIG) samples with nominal composition Y3-xLaxFe5O12 (0< x <0.6) is analysed in this work. The results show a very different behaviour depending on the sintering atmosphere used for the fabrication of the samples. Concretely, for the samples sintered in air, it just have been detected the usual relaxation peak found in YIG at 130 K. However, a new relaxation peak appears around room temperature for the samples sintered in CO2 atmosphere when the La content is at least of 0.3. These results have been interpreted in terms of the formation of a secondary perovskite phase when the La solubility limit is reached. (© 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

Acknowledgements: Authors want to express their gratitude to Dr. P. Davies (Albert Einstein College of Medicine, Bronx, NY, USA) and Lester I. Binder (NorthWestern, Chicago, IL, USA) for the generous gift of mAbs (TG-3, Alz-50, and MC1), and (TauC-3), respectively, and to M. en C. Ivan J. Galván-Mendoza for his support in confocal microscopy, and Ms. Maricarmen De Lorenz for her secretarial assistance. We also want to express our gratitude to the Mexican Families who donate the brain of their loved ones affected with Alzheimer's disease, and made possible our research. This work was financially supported by CONACyT grant, No. 142293 (For R.M).Peer reviewedPublisher PD

Multiplexed vortex beam-based optical tweezers

The design and implementation of a multiplexed spiral phase mask in an experimental optical tweezer setup are presented. This diffractive optical element allows the generation of multiple concentric vortex beams with independent topological charges. The generalization of the phase mask for multiple concentric vortices is also shown. The design for a phase mask of two multiplexed vortices with different topological charges is developed. We experimentally show the transfer of angular momentum to the optically trapped microparticles by enabling orbiting dynamics around the optical axis independently within each vortex. The angular velocity of the confined particles versus the optical power in the focal region is also discussed for different combinations of topological charges

Una nueva hipótesis sobre la sucesión de los bosques tropicales húmedos y secos

In this paper 221 forest trees are grouped according to their habitat preferences into species preferring humid or dry and/or saline habitats or indifferent to the habitat type. Eleven functional traits classes (seeds per tree, seed size, seed weight, seeds per fruit, tolerance to shade, selectivity to habitat, sclerophylly, wood density, foliar area, tree height and tree volume) are arranged 1 to 4 according to a successional gradient. The strategies of forest trees are identified by analyzing the species matrices for humid forest ecosystems (joining species preferring humid habitats together with those indifferent to the habitat type) and for dry and/or saline ecosystems (joining species preferring dry and/or saline habitats and the ones indifferent to the habitat type). Both matrices are processed using the average taxonomic distance as the interval coefficient and by clustering analysis to discover successional organization patterns. The complexity of r-K continuum is discussed by focusing the K behavior of some variables among Pioneers (commonly r strategists) or the r behavior of some variables among Stabilizers (commonly K strategists). A new system of classification is presented as a hypothesis for discovering successional patterns in tropical forests.En el presente artículo agrupamos 221 especies forestales sobre la base de sus preferencias por tipos de hábitat húmedo o seco y/o salino, considerando aparte aquellas que son indiferentes al tipo de hábitat. El sistema de clasificación se sustentó en el empleo de clases de 11 variables funcionales (semillas por árbol, tamaño de las semillas, peso de las semillas, semillas por fruto, tolerancia a la sombra, selectividad al hábitat, esclerofilia, densidad de la madera, área foliar, altura del árbol y volumen del árbol) ordenadas de 1 a 4 de acuerdo con un gradiente sucesional. Las estrategias de las especies arbóreas se identificaron mediante el análisis de las matrices para ecosistemas forestales húmedos (uniendo las especies que prefieren hábitat húmedo con las que son indiferentes al tipo de hábitat) y para ecosistemas secos y/o salinos (uniendo las especies que prefieren hábitat seco y/o salino con las que son indiferentes al tipo de hábitat). Ambas matrices fueron procesadas mediante el uso del coeficiente de distancia taxonómica promedio y por análisis de clasificación para descubrir los patrones de organización sucesional. Se discutieron la complejidad del continuum r-K exponiendo el comportamiento K de algunas variables entre las Pioneras (que comúnmente son estrategas r) y el comportamiento r de algunas variables entre las Estabilizadoras (que comúnmente son estrategas K). Presentamos el nuevo sistema de clasificación como una hipótesis para descubrir los patrones sucesionales en bosques tropicales.Depto. de Biodiversidad, Ecología y EvoluciónFac. de Ciencias BiológicasTRUEInternational Foundation for Science (IFS) (Sweden)MacArthur Foundation and D. W. Reynolds Foundation (USA)David Rockefeller Center for Latin-American Studies (Cambridge, USA)The Ecological Society of America (ESA)( Washington, USA)pu

Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction

The induction of both long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission entails pre- and postsynaptic Ca2+ signals, which represent transient increments in cytoplasmic free Ca2+ concentration. In diverse synapse types, Ca2+ release from intracellular stores contributes to amplify the Ca2+ signals initially generated by activation of neuronal Ca2+ entry pathways. Here, we used hippocampal slices from young male rats to evaluate whether pharmacological activation or inhibition of Ca2+ release from the endoplasmic reticulum (ER) mediated by ryanodine receptor (RyR) channels modifies LTD induction at Schaffer collateral-CA1 synapses. Pre-incubation of slices with ryanodine (1 μM, 1 h) or caffeine (1 mM, 30 min) to promote RyR-mediated Ca2+ release facilitated LTD induction by low frequency stimulation (LFS), but did not affect the amplitude of synaptic transmission, the profiles of field excitatory postsynaptic potentials (fEPSP) or the paired-pulse (PP) responses. Conversely, treatment with inhibitory ryanodine (20 μM, 1 h) to suppress RyR-mediated Ca2+ release prevented LTD induction, but did not affect baseline synaptic transmission or PP responses. Previous literature reports indicate that LTD induction requires presynaptic CaMKII activity. We found that 1 h after applying the LTD induction protocol, slices displayed a significant increase in CaMKII phosphorylation relative to the levels exhibited by un-stimulated (naïve) slices. In addition, LTD induction (1 h) enhanced the phosphorylation of the presynaptic protein Synapsin I at a CaMKII-dependent phosphorylation site, indicating that LTD induction stimulates presynaptic CaMKII activity. Pre-incubation of slices with 20 μM ryanodine abolished the increased CaMKII and Synapsin I phosphorylation induced by LTD, whereas naïve slices pre-incubated with inhibitory ryanodine displayed similar CaMKII and Synapsin I phosphorylation levels as naïve control slices. We posit that inhibitory ryanodine suppressed LTD-induced presynaptic CaMKII activity, as evidenced by the suppression of Synapsin I phosphorylation induced by LTD. Accordingly, we propose that presynaptic RyR-mediated Ca2+ signals contribute to LTD induction at Schaffer collateral-CA1 synapses